Treatment and survival of patients with EGFR-mutated non-small cell lung cancer and leptomeningeal metastasis: A retrospective cohort analysis. Issue 3 (September 2015)

• Record Type: Journal Article
• Authors: Kuiper, Justine L.; Hendriks, Lizza E.; van der Wekken, Anthonie J.; de Langen, Adrianus J.; Bahce, Idris; Thunnissen, Erik; Heideman, Daniëlle A.M.; Berk, Yvonne; Buijs, Ed J.M.; Speel, Ernst-Jan M.; Krouwels, Frans H.; Smit, Hans J.M.; Groen, Harry J.M.; Dingemans, Anne-Marie C.; Smit, Egbert F.
• Is Part Of: Lung cancer. Volume 89:Issue 3(2015:Sep.)
• Page Start: 255
• Page End: 261
• Publication Date: 2015-09
• Subjects: Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2015.05.023
• Languages: English
• ISSNs: 0169-5002

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">This is the largest study reporting on leptomeningeal metastasis (LM) in <italic>EGFR</italic>-mutated NSCLC-patients.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Median survival of <italic>EGFR</italic>-mutated NSCLC-patients with LM was 3.1 months.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Survival after LM-diagnosis in <italic>EGFR</italic>-mutated NSCLC-patients with LM may not be superior compared to existing data on that in <italic>EGFR</italic>-wild type NSCLC patients.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Six- and 12-month survival rates were 43.8% and 18.8%, respectively.</p> </list-item> </list> </p> </sec> </abstract>