PPARα/γ agonists and antagonists differently affect hepatic lipid metabolism, oxidative stress and inflammatory cytokine production in steatohepatitic rats. Issue 1 (September 2015)

• Record Type: Journal Article
• Authors: Zhang, Yan; Cui, Yan; Wang, Xiao-Li; Shang, Xiang; Qi, Zhi-Gang; Xue, Jie; Zhao, Xi; Deng, Min; Xie, Mei-Lin
• Is Part Of: Cytokine. Volume 75:Issue 1(2015)
• Page Start: 127
• Page End: 135
• Publication Date: 2015-09
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.05.031
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Effects of PPARα/γ on rat lipid, oxidative stress and cytokines were investigated.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">PPARγ could counterbalance the adverse effect of PPARα on circulating FFA.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">PPARα/γ agonists might exert a synergic inhibitory effect on liver oxidative stress.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">PPARα/γ agonists synergically decreased the NF-κB expression and cytokine production.</p> </list-item> </list> </p> </sec> </abstract>