Effects of inhaled bronchodilators on lung function and cycling performance in female athletes with and without exercise-induced bronchoconstriction. Issue 5 (September 2015)

• Record Type: Journal Article
• Authors: Koch, Sarah; Karacabeyli, Derin; Galts, Ciaran; MacInnis, Martin J.; Sporer, Benjamin C.; Koehle, Michael S.
• Is Part Of: Journal of science and medicine in sport. Volume 18:Issue 5(2015:Sep.)
• Page Start: 607
• Page End: 612
• Publication Date: 2015-09
• Subjects: Sports sciences -- Periodicals; Sports medicine -- Periodicals; Exercise -- Physiological aspects -- Periodicals; Sports -- physiology -- Periodicals; Sports Medicine -- Periodicals; Sportgeneeskunde; 617.102705
• DOI: 10.1016/j.jsams.2014.07.021
• Languages: English
• ISSNs: 1440-2440

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <title id="sect0010">Objectives</title> <p id="spar0005">Inhaled β<sub>2</sub>-agonists may cause differential effects on lung function and athletic performance in female compared to male athletes. The objective of this study was to compare the effects of inhaled β<sub>2</sub>-agonists on lung function and cycling performance between female athletes with and without exercise-induced bronchoconstriction and with previously published data on men.</p> </sec> <sec> <title id="sect1015">Design</title> <p id="spar1005">Double-blind crossover randomized controlled trial.</p> </sec> <sec> <title id="sect0015">Methods</title> <p id="spar0010">Twenty-one female athletes (6 with exercise-induced bronchoconstriction and 15 without exercise-induced bronchoconstriction) performed a simulated 10-km time-trial on a cycle ergometer 60 min after the inhalation of either 400 μg of salbutamol or placebo. Forced expiratory volume in 1 s, was measured immediately before and 30 min after inhalation. Performance was measured by mean power output over the duration of the time trial.</p> </sec> <sec> <title id="sect0020">Results</title> <p id="spar0015">After salbutamol inhalation, Forced expiratory volume in 1 s improved significantly in athletes with exercise-induced bronchoconstriction (M (SD) = 6.1% (47.6)) and athletes without exercise-induced bronchoconstriction (4.0% (3.1); <italic>p</italic> ≤ 0.02). Mean power output was significantly decreased after salbutamol use (204 W (21)) compared to placebo (208 W (17); <italic>p</italic> = 0.047), regardless of airway hyperresponsiveness. Relative to placebo, salbutamol significantly increased mean oxygen consumption (46.9 mL kg<sup>−1</sup> min<sup>−1</sup> (5.9) vs. 44.8 mL kg<sup>−1</sup> min<sup>−1</sup> (4.0); <italic>p</italic> = 0.049) and significantly decreased cycling economy (72.8 W L<sup>−1</sup> min<sup>−1</sup> (6.8) vs. 76.4 W L<sup>−1</sup> min<sup>−1</sup> (4.3); <italic>p</italic> = 0.01).</p> </sec> <sec> <title id="sect0025">Conclusions</title> <p id="spar0020">The inhalation of salbutamol induced a significant increase in lung function in female athletes, but this increased lung function did not translate to improved exercise performance.</p> </sec> </abstract>