Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma. Issue 13 (September 2015)

• Record Type: Journal Article
• Authors: Tejera-Vaquerizo, Antonio; Nagore, Eduardo; Puig, Susana; Robert, Caroline; Saiag, Philippe; Martín-Cuevas, Paula; Gallego, Elena; Herrera-Acosta, Enrique; Aguilera, José; Malvehy, Josep; Carrera, Cristina; Cavalcanti, Andrea; Rull, Ramón; Vilalta-Solsona, Antonio; Lannoy, Emilie; Boutros, Celine; Benannoune, Naima; Tomasic, Gorana; Aegerte, Philippe; Vidal-Sicart, Sergi; Palou, Josep; Alos, LLúcia; Requena, Celia; Traves, Víctor; Pla, Ángel; Bolumar, Isidro; Soriano, Virtudes; Guillén, Carlos; Herrera-Ceballos, Enrique
• Is Part Of: European journal of cancer. Volume 51:Issue 13(2015:Sep.)
• Page Start: 1780
• Page End: 1793
• Publication Date: 2015-09
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Cancer; Tumors; Electronic journals; Periodicals; Electronic journals; 616.994
• DOI: 10.1016/j.ejca.2015.05.023
• Languages: English
• ISSNs: 0959-8049

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title id="st005">Abstract</title> <sec> <title id="st010">Introduction</title> <p id="sp0005">In patients with primary cutaneous melanoma, there is generally a delay between excisional biopsy of the primary tumour and sentinel-node biopsy. The objective of this study is to analyse the prognostic implications of this delay.</p> </sec> <sec> <title id="st015">Patients and method</title> <p id="sp0010">This was an observational, retrospective, cohort study in four tertiary referral hospitals. A total of 1963 patients were included. The factor of interest was the interval between the date of the excisional biopsy of the primary melanoma and the date of the sentinel-node biopsy (delay time) in the prognosis. The primary outcome was melanoma-specific survival and disease-free survival.</p> </sec> <sec> <title id="st020">Results</title> <p id="sp0015">A delay time of 40 days or less (hazard ratio (HR), 1.7; confidence interval (CI), 1.2–2.5) increased Breslow thickness (Breslow ⩾2 mm, HR, >3.7; CI, 1.4–10.7), ulceration (HR, 1.6; CI, 1.1–2.3), sentinel-node metastasis (HR, 2.9; CI, 1.9–4.2), and primary melanoma localised in the head or neck were independently associated with worse melanoma-specific survival (all <italic>P</italic> < 0.03). The stratified analysis showed that the effect of delay time was at the expense of the patients with a negative sentinel-node biopsy and without regression.</p> </sec> <sec> <title id="st025">Conclusion</title> <p id="sp0020">Early sentinel-node biopsy is associated with worse survival in patients with cutaneous melanoma.</p> </sec> </abstract>