Feasibility and repeatability of PET with the hypoxia tracer [18F]HX4 in oesophageal and pancreatic cancer. Issue 1 (July 2015)

• Record Type: Journal Article
• Authors: Klaassen, Remy; Bennink, Roelof J.; van Tienhoven, Geertjan; Bijlsma, Maarten F.; Besselink, Marc G.H.; van Berge Henegouwen, Mark I.; Wilmink, Johanna W.; Nederveen, Aart J.; Windhorst, Albert D.; Hulshof, Maarten C.C.M.; van Laarhoven, Hanneke W.M.
• Is Part Of: Radiotherapy and oncology. Volume 116:Issue 1(2015:Jul.)
• Page Start: 94
• Page End: 99
• Publication Date: 2015-07
• Subjects: Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2015.05.009
• Languages: English
• ISSNs: 0167-8140

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title id="st005">Abstract</title> <sec> <title id="st010">Background and purpose</title> <p id="sp0005">To investigate the feasibility and to determine the repeatability of recurrent [<sup>18</sup>F]HX4 PET scans in patients with oesophageal (EC) and pancreatic (PC) cancer.</p> </sec> <sec> <title id="st015">Materials and methods</title> <p id="sp0010">32 patients were scanned in total; seven patients (4 EC/3 PC) were scanned 2, 3 and 4 h post injection (PI) of [<sup>18</sup>F]HX4 and 25 patients (15 EC/10 PC) were scanned twice 3.5 h PI, on two separate days (median 4, range 1–9 days). Maximum tumour to background ratio (TBRmax) and the tumour hypoxic volume (HV) (TBR > 1.0) were calculated. Repeatability was assessed using Bland–Altman analysis. Agreement in localization was calculated as the distance between the centres of mass in the HVs.</p> </sec> <sec> <title id="st020">Results</title> <p id="sp0015">For EC, the TBRmax in the tumour (mean ± SD) was 1.87 ± 0.46 with a coefficient of repeatability (CoR) of 0.53 (28% of mean). The HV ranged from 3.4 to 98.8 ml with a CoR of 5.1 ml. For PC, the TBRmax was 1.72 ± 0.23 with a CoR of 0.27 (16% of mean). The HV ranged from 4.6 to 104.0 ml with a CoR of 7.8 ml. The distance between the centres of mass in the HV was 2.2 ± 1.3 mm for EC and 2.1 ± 1.5 mm for PC.</p> </sec> <sec> <title id="st025">Conclusions</title> <p id="sp0020">PET scanning with [<sup>18</sup>F]HX4 was feasible in both EC and PC patients. Amount and location of elevated [<sup>18</sup>F]HX4 uptake showed good repeatability, suggesting [<sup>18</sup>F]HX4 PET could be a promising tool for radiation therapy planning and treatment response monitoring in EC and PC patients.</p> </sec> </abstract>