IAEA randomised trial of optimal single dose radiotherapy in the treatment of painful bone metastases. Issue 1 (July 2015)

• Record Type: Journal Article
• Authors: Hoskin, Peter; Rojas, Ana; Fidarova, Elena; Jalali, Rakesh; Mena Merino, Ana; Poitevin, Adela; Oucrif, Seam; Abdelwahab, Sherif; Kochbati, Lotfi; Plieskiene, Aista; Casas, Francesc; Stojanovic, Susana; Schneider, Günther; Jeremic, Branislav
• Is Part Of: Radiotherapy and oncology. Volume 116:Issue 1(2015:Jul.)
• Page Start: 10
• Page End: 14
• Publication Date: 2015-07
• Subjects: Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2015.05.008
• Languages: English
• ISSNs: 0167-8140

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title id="st005">Abstract</title> <sec> <title id="st010">Background</title> <p id="sp0005">To determine the optimal single-dose radiotherapy schedule for pain from bone metastases in a multi-centre, international, randomised trial.</p> </sec> <sec> <title id="st015">Patients and methods</title> <p id="sp0010">651 patients were randomised to either 8 Gy (<italic>n</italic> = 325) or 4 Gy (<italic>n</italic> = 326) radiotherapy. Pain at 4, 8, 12, 24 and 52 weeks was assessed using a Categorical Scale (CS) and a Visual Analogue Scale (VAS). The primary endpoint was response at 4 weeks.</p> </sec> <sec> <title id="st020">Results</title> <p id="sp0015">There was no significant difference in patient demographics and other co-variates. The complete response (CR) rate and ORR (complete or partial response) for all follow-up times were higher after 8 Gy (<italic>p</italic> = 0.02). The Kaplan–Meier actuarial rate (categorical scale) at 4 weeks for ORR was 80% after 8 Gy compared to 68% after 4 Gy (<italic>p</italic> = 0.0015). 117 re-treatments were given of which 72 were in the 4 Gy group and 45 in 8 Gy arm (<italic>p</italic> = 0.01).</p> </sec> <sec> <title id="st025">Conclusions</title> <p id="sp0020">There was a marked consistent difference in pain relief at all time points in favour of 8 Gy. These data reinforce the case for single dose 8 Gy radiotherapy to be recommended for metastatic bone pain in all healthcare settings.</p> </sec> </abstract>