RANKL pretreatment plays an important role in the differentiation of pit-forming osteoclasts induced by TNF-α on murine bone marrow macrophages. Issue 9 (September 2015)

• Record Type: Journal Article
• Authors: Yamashita, Yasunori; Ukai, Takashi; Nakamura, Hirotaka; Yoshinaga, Yasunori; Kobayashi, Hiroki; Takamori, Yuzo; Noguchi, Satoshi; Yoshimura, Atsutoshi; Hara, Yoshitaka
• Is Part Of: Archives of oral biology. Volume 60:Issue 9(2015:Sep.)
• Page Start: 1273
• Page End: 1282
• Publication Date: 2015-09
• Subjects: Mouth -- Periodicals; Mouth -- Diseases -- Periodicals; Dentistry -- Periodicals; Electronic journals; 617.6005
• DOI: 10.1016/j.archoralbio.2015.06.002
• Languages: English
• ISSNs: 0003-9969

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We examined the condition of acceleration of osteoclast formation by TNF-α.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">We checked whether TNF-α after RANKL pretreatment could promote resorbing activity.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">TNF-α after 10 ng/mL RANKL pretreatment significantly promoted osteoclast formation.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">TNF-α after 10 ng/mL RANKL pretreatment dynamically generated pit-forming osteoclasts.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">The effects of TNF-α after RANKL pretreatment might be independent of RANKL.</p> </list-item> </list> </p> </sec> </abstract>