Graphene Oxides Show Angiogenic Properties. Issue 11 (1st June 2015)

• Record Type: Journal Article
• Authors: Mukherjee, Sudip; Sriram, Pavithra; Barui, Ayan Kumar; Nethi, Susheel Kumar; Veeriah, Vimal; Chatterjee, Suvro; Suresh, Kattimuttathu Ittara; Patra, Chitta Ranjan
• Is Part Of: Advanced healthcare materials. Volume 4:Issue 11(2015)
• Page Start: 1722
• Page End: 1732
• Publication Date: 2015-06-01
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201500155
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Angiogenesis, a process resulting in the formation of new capillaries from the pre‐existing vasculature plays vital role for the development of therapeutic approaches for cancer, atherosclerosis, wound healing, and cardiovascular diseases. In this report, the synthesis, characterization, and angiogenic properties of graphene oxide (GO) and reduced graphene oxide (rGO) have been demonstrated, observed through several in vitro and in vivo angiogenesis assays. The results here demonstrate that the intracellular formation of reactive oxygen species and reactive nitrogen species as well as activation of phospho‐eNOS and phospho‐Akt might be the plausible mechanisms for GO and rGO induced angiogenesis. The results altogether suggest the possibilities for the development of alternative angiogenic therapeutic approach for the treatment of cardiovascular related diseases where angiogenesis plays a significant role.</p> </abstract>