Multilayered, Hyaluronic Acid‐Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer‐Stromal Cell Cocultures. Issue 11 (9th June 2015)

• Record Type: Journal Article
• Authors: Engel, Brian J.; Constantinou, Pamela E.; Sablatura, Lindsey K.; Doty, Nathaniel J.; Carson, Daniel D.; Farach‐Carson, Mary C.; Harrington, Daniel A.; Zarembinski, Thomas I.
• Is Part Of: Advanced healthcare materials. Volume 4:Issue 11(2015)
• Page Start: 1664
• Page End: 1674
• Publication Date: 2015-06-09
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201500258
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adhm201500258-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Validation of a high‐throughput compatible 3D hyaluronic acid hydrogel coculture of cancer cells with stromal cells.</bold> The multilayered hyaluronic acid hydrogels improve drug screening predictability as evaluated with a panel of clinically relevant chemotherapeutics in both prostate and endometrial cancer cell lines compared to 2D culture. <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj2cqns2gj" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>