Detection of indoxyl sulfate levels in dogs and cats suffering from naturally occurring kidney diseases. Issue 3 (September 2015)

• Record Type: Journal Article
• Authors: Cheng, F.P.; Hsieh, M.J.; Chou, C.C.; Hsu, W.L.; Lee, Y.J.
• Is Part Of: Veterinary journal. Volume 205:Issue 3(2015)
• Page Start: 399
• Page End: 403
• Publication Date: 2015-09
• Subjects: Veterinary medicine -- Periodicals; 636
• DOI: 10.1016/j.tvjl.2015.04.017
• Languages: English
• ISSNs: 1090-0233

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Plasma concentrations of indoxyl sulfate (IS), a protein-bound uraemic toxin, are correlated with renal disease severity.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Plasma IS concentrations of dogs and cats were determined by HPLC with a fluorescence detector.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Both azotaemic dogs and cats had significantly higher plasma IS levels than non-azotaemic controls.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">The plasma IS level was significantly correlated with BUN, serum creatinine and phosphate levels.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">The IS concentration increased gradually as CKD severity increased, with the highest level in IRIS stage 4.</p> </list-item> </list> </p> </sec> </abstract>