Intraosseous infusion of the distal phalanx compared to systemic intravenous infusion for marimastat delivery to equine lamellar tissue. Issue 3 (September 2015)

• Record Type: Journal Article
• Authors: Underwood, Claire; Collins, Simon N.; van Eps, Andrew W.; Mills, Paul C.; Allavena, Rachel E.; Bailey, Simon R.; Medina Torres, Carlos E.; Meizler, Alon; Pollitt, Christopher C.
• Is Part Of: Veterinary journal. Volume 205:Issue 3(2015)
• Page Start: 357
• Page End: 363
• Publication Date: 2015-09
• Subjects: Veterinary medicine -- Periodicals; 636
• DOI: 10.1016/j.tvjl.2015.05.010
• Languages: English
• ISSNs: 1090-0233

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Ultrafiltration was used to collect lamellar interstitial fluid for pharmacokinetic analyses.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">IOIDP with marimastat results in similar lamellar marimastat concentrations to systemic intravenous constant rate infusion.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Further refinement of the IOIDP technique is necessary if it is to be useful for local lamellar drug delivery.</p> </list-item> </list> </p> </sec> </abstract>