Pharmacokinetics and antinociceptive effects of tramadol and its metabolite O-desmethyltramadol following intravenous administration in sheep. Issue 3 (September 2015)

• Record Type: Journal Article
• Authors: Bortolami, E.; della Rocca, G.; Di Salvo, A.; Giorgi, M.; Kim, T.W.; Isola, M.; De Benedictis, G.M.
• Is Part Of: Veterinary journal. Volume 205:Issue 3(2015)
• Page Start: 404
• Page End: 409
• Publication Date: 2015-09
• Subjects: Veterinary medicine -- Periodicals; 636
• DOI: 10.1016/j.tvjl.2015.04.011
• Languages: English
• ISSNs: 1090-0233

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Six sheep were administered 4 and 6 mg/kg tramadol and saline intravenously.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Pharmacokinetic analysis and mechanical nociceptive threshold test were performed.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Pharmacokinetic parameters of tramadol were similar after the two doses.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">No mechanical antinociceptive effects of tramadol were reported.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">Further studies are warranted to assess the efficacy of tramadol in sheep.</p> </list-item> </list> </p> </sec> </abstract>