Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment. Issue 8 (August 2015)

• Record Type: Journal Article
• Authors: Ellaithy, Amr; Younkin, Jason; González-Maeso, Javier; Logothetis, Diomedes E.
• Is Part Of: Trends in neurosciences. Volume 38:Issue 8(2015)
• Page Start: 506
• Page End: 516
• Publication Date: 2015-08
• Subjects: Neurology -- Periodicals; Neurophysiology -- Periodicals; Neurobiology -- Periodicals; 612.8
• DOI: 10.1016/j.tins.2015.06.002
• Languages: English
• ISSNs: 0166-2236

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">mGlu₂R activation is a potential therapeutic strategy for schizophrenia.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Unlike orthosteric agonists, positive allosteric modulators have a unique ability to fine-tune physiological responses.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Chronic atypical antipsychotic therapy may reduce the efficacy of mGlu₂R antipsychotics.</p> </list-item> </list> </p> </sec> </abstract>