K-Cl cotransporters, cell volume homeostasis, and neurological disease. Issue 8 (August 2015)

• Record Type: Journal Article
• Authors: Kahle, Kristopher T.; Khanna, Arjun R.; Alper, Seth L.; Adragna, Norma C.; Lauf, Peter K.; Sun, Dandan; Delpire, Eric
• Is Part Of: Trends in molecular medicine. Volume 21:Issue 8(2015)
• Page Start: 513
• Page End: 523
• Publication Date: 2015-08
• Subjects: Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; Physiology, Pathological -- Periodicals; 572.8
• DOI: 10.1016/j.molmed.2015.05.008
• Languages: English
• ISSNs: 1471-4914

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0045"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0225">KCCs have roles in the nervous system beyond modulating GABAergic signaling.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0230">KCCs regulate nervous system cell volume, and are mutated in neurological disease.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0235">WNK-SPAK kinases modulate volume-sensitive KCC activity.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0240">Antagonizing WNK-SPAK-mediated KCC phosphorylation may hold therapeutic promise.</p> </list-item> </list> </p> </sec> </abstract>