Dynamic aberrant NF-κB spurs tumorigenesis: A new model encompassing the microenvironment. Issue 4 (August 2015)

• Record Type: Journal Article
• Authors: Vlahopoulos, Spiros A.; Cen, Osman; Hengen, Nina; Agan, James; Moschovi, Maria; Critselis, Elena; Adamaki, Maria; Bacopoulou, Flora; Copland, John A.; Boldogh, Istvan; Karin, Michael; Chrousos, George P.
• Is Part Of: Cytokine & growth factor reviews. Volume 26:Issue 4(2015)
• Page Start: 389
• Page End: 403
• Publication Date: 2015-08
• Subjects: Cytokines -- Periodicals; 571.84
• DOI: 10.1016/j.cytogfr.2015.06.001
• Languages: English
• ISSNs: 1359-6101

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">During inflammation, cytokines induce a sequential activation of different cell types.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Malignant cells can express gene cohorts from different stages of the inflammatory cascade.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Dysregulation of NF-κB enables combining programs of stem cells with differentiated cells.</p> </list-item> <list-item id="lsti0016"> <label></label> <p id="par0016">The result is an aberrant interaction with the host tissue and the immune system.</p> </list-item> <list-item id="lsti0017"> <label></label> <p id="par0017">Disruption of essential mediators of homeostasis has far-ranging effects on the organism.</p> </list-item> </list> </p> </sec> </abstract>