99mTc-DTPA-bis-c(RGDfK) a potential alpha(v)beta3 integrin based homobivalent radioligand for imaging neoangiogenesis in malignant glioma and melanoma1. Issue 74 (13th August 2015)

• Record Type: Journal Article
• Authors: Debordeaux, Frédéric; Schulz, Jürgen; Savona-Baron, Catherine; Hazari, Puja Panwar; Lervat, Cyril; Mishra, Anil Kumar; Ries, Colette; Barthe, Nicole; Vergier, Béatrice; Fernandez, Philippe
• Is Part Of: RSC advances. Volume 5:Issue 74(2015)
• Page Start: 60161
• Page End: 60171
• Publication Date: 2015-08-13
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra09119e
• Languages: English
• ISSNs: 2046-2069

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj26bcng3q" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />A new ^99mTc-labeled bivalent DTPA-bis-c(RGDfK) conjugate has been developed and successfully synthesized. Promising results have been obtained for its preclinical evaluation on human glioma and melanoma tumor expressing α_vβ₃ targets.</p> </abstract>