A new quinoxaline-containing peptide induces apoptosis in cancer cells by autophagy modulation1. Issue 8 (14th August 2015)

• Record Type: Journal Article
• Authors: Zamudio-Vázquez, Rubí; Ivanova, Saška; Moreno, Miguel; Hernandez-Alvarez, Maria Isabel; Giralt, Ernest; Bidon-Chanal, Axel; Zorzano, Antonio; Albericio, Fernando; Tulla-Puche, Judit
• Is Part Of: Chemical science. Volume 6:Issue 8(2015:Aug.)
• Page Start: 4537
• Page End: 4549
• Publication Date: 2015-08-14
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5sc00125k
• Languages: English
• ISSNs: 2041-6520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj26b8jgv2" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />The most cytotoxic compound from a library of quinoxaline-containing peptides is endocyted into HeLa cells, accumulates in acidic compartments, and blocks autophagy by altering lysosomal function, leading to apoptosis activation.</p> </abstract>