Invader probes: harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications1. Issue 8 (14th August 2015)

• Record Type: Journal Article
• Authors: Guenther, Dale C.; Anderson, Grace H.; Karmakar, Saswata; Anderson, Brooke A.; Didion, Bradley A.; Guo, Wei; Verstegen, John P.; Hrdlicka, Patrick J.
• Is Part Of: Chemical science. Volume 6:Issue 8(2015:Aug.)
• Page Start: 5006
• Page End: 5015
• Publication Date: 2015-08-14
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5sc01238d
• Languages: English
• ISSNs: 2041-6520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj26b8jbnp" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />Optimized Invader probes enable efficient (<italic>C</italic>₅₀ &lt; 1 μM), fast (<italic>t</italic>₅₀ &lt; 3 h), kinetically stable (&gt;24 h), and single nucleotide specific recognition of DNA targets.</p> </abstract>