Quantification of myocardial blood flow with dynamic perfusion 3.0 Tesla MRI: Validation with 15o‐water PET. Issue 3 (30th December 2014)

• Record Type: Journal Article
• Authors: Tomiyama, Yuuki; Manabe, Osamu; Oyama‐Manabe, Noriko; Naya, Masanao; Sugimori, Hiroyuki; Hirata, Kenji; Mori, Yuki; Tsutsui, Hiroyuki; Kudo, Kohsuke; Tamaki, Nagara; Katoh, Chietsugu
• Is Part Of: Journal of magnetic resonance imaging. Volume 42:Issue 3(2015)
• Page Start: 754
• Page End: 762
• Publication Date: 2014-12-30
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24834
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24834-sec-0001" sec-type="section"> <title>Background</title> <p>To develop and validate a method for quantifying myocardial blood flow (MBF) using dynamic perfusion magnetic resonance imaging (MBF<sub>MRI</sub>) at 3.0 Tesla (T) and compare the findings with those of <sup>15</sup>O‐water positron emission tomography (MBF<sub>PET</sub>).</p> </sec> <sec id="jmri24834-sec-0002" sec-type="section"> <title>Methods</title> <p>Twenty healthy male volunteers underwent magnetic resonance imaging (MRI) and <sup>15</sup>O‐water positron emission tomography (PET) at rest and during adenosine triphosphate infusion. The single‐tissue compartment model was used to estimate the inflow rate constant (K1). We estimated the extraction fraction of Gd‐DTPA using K1 and MBF values obtained from <sup>15</sup>O‐water PET for the first 10 subjects. For validation, we calculated MBF<sub>MRI</sub> values for the remaining 10 subjects and compared them with the MBF<sub>PET</sub> values<sub>.</sub> In addition, we compared MBF<sub>MRI</sub> values of 10 patients with coronary artery disease with those of healthy subjects.</p> </sec> <sec id="jmri24834-sec-0003" sec-type="section"> <title>Results</title> <p>The mean resting and stress MBF<sub>MRI</sub> values were 0.76 ± 0.10 and 3.04 ± 0.82 mL/min/g, respectively, and showed excellent correlation with the mean MBF<sub>PET</sub> values (r = 0.96, <italic>P</italic> < 0.01). The mean stress MBF<sub>MRI</sub> value was significantly lower for the patients (1.92 ± 0.37) than for the healthy subjects (<italic>P</italic> < 0.001).</p> </sec> <sec id="jmri24834-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The use of dynamic perfusion MRI at 3T is useful for estimating MBF and can be applied for patients with coronary artery disease. J. Magn. Reson. Imaging 2015;42:754–762.</p> </sec> </abstract>