Comparison of noncontrast MRI magnetization transfer and T2‐Weighted signal intensity ratios for detection of bowel wall fibrosis in a Crohn's disease animal model. Issue 3 (13th December 2014)

• Record Type: Journal Article
• Authors: Dillman, Jonathan R.; Swanson, Scott D.; Johnson, Laura A.; Moons, David S.; Adler, Jeremy; Stidham, Ryan W.; Higgins, Peter D.R.
• Is Part Of: Journal of magnetic resonance imaging. Volume 42:Issue 3(2015)
• Page Start: 801
• Page End: 810
• Publication Date: 2014-12-13
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24815
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24815-sec-0001" sec-type="section"> <title>Purpose</title> <p>To compare the abilities of magnetization transfer magnetic resonance imaging (MT‐MRI) and <italic>T</italic><sub>2</sub>‐weighted signal intensity (<italic>T</italic><sub>2</sub>WSI) ratios to detect intestinal fibrosis in a Crohn's disease animal model.</p> </sec> <sec id="jmri24815-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Ten rats ("Group 1") received one trinitrobenzenesulfonic acid enema to induce acute colonic inflammation, while 10 additional animals ("Group 2") received multiple enemas to induce colonic inflammation and fibrosis. Gradient recalled‐echo MT‐MRI (5 and 10 kHz off‐resonance) and <italic>T</italic><sub>2</sub>‐weighted spin‐echo imaging were performed 2 days after the last enema. MT ratios (MTR) and <italic>T</italic><sub>2</sub>WSI ratios were calculated in the area of greatest colonic thickening. Bowel wall MTR, bowel wall MTR normalized to paraspinous muscle MTR ("normalized MTR"), and <italic>T</italic><sub>2</sub>WSI ratios were compared between animal groups using Student's <italic>t</italic>‐test.</p> </sec> <sec id="jmri24815-sec-0003" sec-type="section"> <title>Results</title> <p>At 10 kHz off‐resonance, mean bowel wall MTR for Group 1 was 24.8 ± 3.1% vs. 30.3 ± 3.2% for Group 2 (<italic>P</italic> = 0.001). Mean normalized MTR was 0.45 ± 0.05 for Group 1 and 0.58 ± 0.08 for Group 2 (<italic>P</italic> = 0.0003). At 5 kHz off‐resonance, mean bowel wall MTR for Group 1 was 34.7 ± 5.2% vs. 40.3 ± 3.6% for Group 2 (<italic>P</italic> = 0.015). Mean normalized MTR was 0.53 ± 0.08 for Group 1 and 0.64 ± 0.07 for Group 2 (<italic>P</italic> = 0.003). Mean <italic>T</italic><sub>2</sub>WSI ratio was 5.32 ± 0.98 for Group 1 and 3.01 ± 0.66 for group 2 (<italic>P</italic> < 0.0001). Mean <italic>T</italic><sub>2</sub>WSI ratio/MTR (10 kHz off‐resonance) was 12.06 ± 2.70 for Group 1 and 5.22 ± 1.29 for Group 2 (<italic>P</italic> < 0.0001), with an ROC c‐statistic of 0.98.</p> </sec> <sec id="jmri24815-sec-0004" sec-type="section"> <title>Conclusion</title> <p>MTR and <italic>T</italic><sub>2</sub>WSI ratios detect bowel wall fibrosis in a Crohn's disease animal model. J. Magn. Reson. Imaging 2015;42:801–810.</p> </sec> </abstract>