Clinical implementation of islet transplantation: A current assessment. Issue 6 (18th June 2015)

• Record Type: Journal Article
• Authors: Bottino, Rita; Trucco, Massimo
• Is Part Of: Pediatric diabetes. Volume 16:Issue 6(2015:Oct.)
• Page Start: 393
• Page End: 401
• Publication Date: 2015-06-18
• Subjects: Diabetes in children -- Periodicals; 616.462
• DOI: 10.1111/pedi.12287
• Languages: English
• ISSNs: 1399-543X

Abstract

<abstract abstract-type="main" id="pedi12287-abs-0001"> <title>Abstract</title> <p id="pedi12287-para-0001">Beta‐cell replacement is the only physiologically relevant alternative to insulin injections in patients with type 1 diabetes (T1D). Pancreas and islet transplantation from deceased organ donors can provide a new beta‐cell pool to produce insulin, help blood glucose management, and delay secondary diabetes complications. For children and adolescents with T1D, whole pancreas transplantation is not a viable option because of surgical complications, whereas islet transplantation, even if it is procedurally simpler, must still overcome the burden of immunosuppression to become a routine therapy for children in the future.</p> </abstract>