Utility of algorithm‐based chemoradioselection in the treatment for advanced hypopharyngeal carcinoma. Issue 9 (24th July 2014)

• Record Type: Journal Article
• Authors: Masuda, Muneyuki; Matsuo, Mioko; Aso, Takeichiro; Kiyohara, Hideyuki; Rikimaru, Fumihide; Kunitake, Naonobu; Higaki, Yuichiro
• Is Part Of: Head & neck. Volume 37:Issue 9(2015:Sep.)
• Page Start: 1290
• Page End: 1296
• Publication Date: 2014-07-24
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23759
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="hed23759-sec-0001" sec-type="section"> <title>Background</title> <p>Current organ‐preserving dose‐intensified modalities have apparently reached the limit of human tolerance. To optimize the therapeutic ratio, we evaluated the utility of a chemoradioselection strategy for the treatment of advanced hypopharyngeal carcinoma.</p> </sec> <sec id="hed23759-sec-0002" sec-type="section"> <title>Methods</title> <p>Fifty‐five patients with advanced hypopharyngeal carcinoma were enrolled in our algorithm‐based protocol. After 40 Gy of concurrent chemoradiation therapy (CCRT), patients who were chemoradioselected (chemoradioselected group, complete response [CR] at the primary site) received further 30 Gy of CCRT up to 70 Gy, whereas the remaining nonchemoradioselected (nonchemoradioselected group) patients underwent radical surgery.</p> </sec> <sec id="hed23759-sec-0003" sec-type="section"> <title>Results</title> <p>Based on this algorithm, 27 patients were chemoradioselected and 28 nonchemoradioselected. The 5‐year cumulative disease‐specific and overall survival (OS) rates were 76% and 65%, respectively. The chemoradioselected group demonstrated favorable laryngoesophageal dysfunction‐free survival (77% at 3 years).</p> </sec> <sec id="hed23759-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Although preliminary, our results indicate that algorithm‐based chemoradioselection may provide a novel platform for improving the treatment of advanced hypopharyngeal carcinoma by providing the complete advantages of CCRT and radical surgical resection. © 2014 Wiley Periodicals, Inc. <italic>Head Neck</italic> 37: 1290–1296, 2015</p> </sec> </abstract>