Lymph node density as an independent predictor of cancer‐specific mortality in patients with lymph node–positive laryngeal squamous cell carcinoma after laryngectomy. Issue 9 (19th July 2014)

• Record Type: Journal Article
• Authors: Ryu, In Sun; Roh, Jong‐Lyel; Cho, Kyung‐Ja; Choi, Seung‐Ho; Nam, Soon Yuhl; Kim, Sang Yoon
• Is Part Of: Head & neck. Volume 37:Issue 9(2015:Sep.)
• Page Start: 1319
• Page End: 1325
• Publication Date: 2014-07-19
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23750
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="hed23750-sec-0001" sec-type="section"> <title>Background</title> <p>We examined the prognostic value of lymph node density in predicting cancer‐specific mortality (CSM) for patients with lymph nodes positive (pN+) laryngeal squamous cell carcinoma (SCC) after laryngectomy.</p> </sec> <sec id="hed23750-sec-0002" sec-type="section"> <title>Methods</title> <p>The records of 156 patients with laryngeal SCC who initially underwent curative resection of the primary tumor combined with neck dissection were reviewed.</p> </sec> <sec id="hed23750-sec-0003" sec-type="section"> <title>Results</title> <p>The 5‐year cumulative incidence of CSM was 20.4%. N classification and extralaryngeal spread (ELS) were independent variables for CSM in all patients. Univariate analyses in 71 pN+ patients showed that ELS, number of positive lymph nodes >4, and lymph node density >0.044 were significantly associated with increased CSM, whereas pN classification was not (<italic>p</italic> = .218). On multivariate analysis, lymph node density ≥0.044 remained an independent predictor of CSM (<italic>p</italic> = .001).</p> </sec> <sec id="hed23750-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Among the pN+ patients with laryngeal SCC, no pN classification but lymph node density was noted to have an independent impact on CSM. © 2014 Wiley Periodicals, Inc. <italic>Head Neck</italic> 37: 1319–1325, 2015</p> </sec> </abstract>