Effects of IL6 C‐634G polymorphism on tooth loss and their interaction with smoking habits. (14th July 2015)

• Record Type: Journal Article
• Authors: Suma, S; Naito, M; Wakai, K; Sasakabe, T; Hattori, Y; Okada, R; Kawai, S; Hishida, A; Morita, E; Nakagawa, H; Tamura, T; Hamajima, N
• Is Part Of: Oral diseases. Volume 21:Number 6(2015:Oct.)
• Page Start: 807
• Page End: 813
• Publication Date: 2015-07-14
• Subjects: Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.12352
• Languages: English
• ISSNs: 1354-523X

Abstract

<abstract abstract-type="main" id="odi12352-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="odi12352-sec-0001" sec-type="section"> <title>Objective</title> <p>To examine the association between an <italic>IL6</italic> (Interleukin‐6) polymorphism (C‐634G or rs1800796) and tooth loss, and an interaction between the polymorphism and smoking habits for the loss.</p> </sec> <sec id="odi12352-sec-0002" sec-type="section"> <title>Material and Methods</title> <p>Our subjects were 4917 check‐up examinees ages 35–69. They reported tooth loss and lifestyle in a questionnaire. We regressed the number of teeth on the <italic>IL6</italic> genotype, gender, age, smoking, drinking, diabetes, hypertension, physical activity, energy intake, education, and brushing. We further estimated multivariate‐adjusted odds ratios (ORs) for having <20 teeth.</p> </sec> <sec id="odi12352-sec-0003" sec-type="section"> <title>Results</title> <p>Participants with a GG genotype tended to have less teeth than those with CC;<italic> β</italic> = −0.798 (95% confidence interval [CI] = −1.501–−0.096). Subjects with a GG genotype were more likely to have <20 teeth than those with CC; OR was 1.56 (95% CI = 1.08–2.25). Association between current smoking and tooth loss was stronger among those with GG than among those with CC. In a multiple regression analysis, a significant interaction was found between GG genotype and current smoking in the prediction of tooth loss (<italic>P </italic>=<italic> </italic>0.018).</p> </sec> <sec id="odi12352-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The <italic>IL6</italic> C‐634G polymorphism was significantly associated with tooth loss. Our results suggest greater effects of smoking on tooth loss in GG genotype individuals.</p> </sec> </abstract>