Ultrasmall particles for Gd‐MRI and 68Ga‐PET dual imaging. (5th December 2014)

• Record Type: Journal Article
• Authors: Truillet, Charles; Bouziotis, Penelope; Tsoukalas, Charalambos; Brugière, Jérémy; Martini, Matteo; Sancey, Lucie; Brichart, Thomas; Denat, Franck; Boschetti, Frédéric; Darbost, Ulrich; Bonnamour, Isabelle; Stellas, Dimitris; Anagnostopoulos, Constantinos D.; Koutoulidis, Vassilis; Moulopoulos, Lia A.; Perriat, Pascal; Lux, François; Tillement, Olivier
• Is Part Of: Contrast media & molecular imaging. Volume 10:Number 4(2015:Jul./Aug.)
• Page Start: 309
• Page End: 319
• Publication Date: 2014-12-05
• Subjects: Diagnostic imaging -- Periodicals; Magnetic resonance imaging -- Periodicals; Contrast media (Diagnostic imaging) -- Periodicals; Contrast Media -- Periodicals; Diagnostic Imaging -- Periodicals; Substances de contraste -- Périodiques; Diagnostics moléculaires -- Périodiques; Imagerie médicale; Substance de contraste; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.0754
• DOI: 10.1002/cmmi.1633
• Languages: English
• ISSNs: 1555-4309

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Nanoparticles made of a polysiloxane matrix and surrounded by 1, 4, 7, 10‐tetraazacyclododecane‐1‐glutaric anhydride‐4, 7, 10‐triacetic acid (DOTAGA)[Gd³⁺] and 2, 2'‐(7‐(1‐carboxy‐4‐((2, 5‐dioxopyrrolidin‐1‐yl)oxy)‐4‐oxobutyl)‐1, 4, 7‐triazonane‐1, 4‐diyl)diacetic acid) NODAGA[⁶⁸Ga³⁺] have been synthesized for positron emission tomography/magnetic resonance (PET/MRI) dual imaging. Characterizations were carried out in order to determine the nature of the ligands available for radiolabelling and to quantify them. High radiolabelling purity (&gt;95%) after ⁶⁸Ga labelling was obtained. The MR and PET images demonstrate the possibility of using the nanoparticles for a combined PET/MR imaging scanner. The images show fast renal elimination of the nanoparticles after intravenous injection.Copyright © 2014 John Wiley &amp; Sons, Ltd.</p> </abstract>