Factors affecting levels of circulating cell‐free fetal DNA in maternal plasma and their implications for noninvasive prenatal testing. (14th July 2015)

• Record Type: Journal Article
• Authors: Kinnings, Sarah L.; Geis, Jennifer A.; Almasri, Eyad; Wang, Huiquan; Guan, Xiaojun; McCullough, Ron M.; Bombard, Allan T.; Saldivar, Juan‐Sebastian; Oeth, Paul; Deciu, Cosmin
• Is Part Of: Prenatal diagnosis. Volume 35:Number 8(2015:Aug.)
• Page Start: 816
• Page End: 822
• Publication Date: 2015-07-14
• Subjects: Prenatal diagnosis -- Periodicals; Fetus -- Diseases -- Diagnosis -- Periodicals; Electronic journals; 618.32075
• DOI: 10.1002/pd.4625
• Languages: English
• ISSNs: 0197-3851

Abstract

<abstract abstract-type="short"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>What's already known about this topic?</bold> <list id="pd4625-list-0001" list-type="bullet"> <list-item id="pd4625-li-0001"> <p>Sufficient fetal‐to‐total DNA fraction ('fetal fraction') of a maternal plasma sample is required for accurate aneuploidy detection via noninvasive prenatal testing.</p> </list-item> <list-item id="pd4625-li-0002"> <p>Fetal fraction increases with gestational age and decreases with maternal weight, which also increases with gestational age.</p> </list-item> <list-item id="pd4625-li-0003"> <p>When compared with euploid samples, an overall increase in fetal fraction in T21‐positive samples and a decrease in fetal fraction in T18‐positive and T13‐positive samples is observed.</p> </list-item> </list> </p> <p> <bold>What does this study add?</bold> <list id="pd4625-list-0002" list-type="bullet"> <list-item id="pd4625-li-0004"> <p>This is the largest known study size from which to assess the effects of maternal and fetal factors on the fetal fraction.</p> </list-item> <list-item id="pd4625-li-0005"> <p>The effects of maternal weight, body mass index, and blood volume on fetal fraction are compared.</p> </list-item> <list-item id="pd4625-li-0006"> <p>The effect of fetal aneuploidy status on the fetal fraction is shown across different gestational ages.</p> </list-item> <list-item id="pd4625-li-0007"> <p>Multiple measurements of fetal fraction per patient are compared both from the same and different blood draws.</p> </list-item> </list> © 2015 John Wiley & Sons, Ltd.</p> </abstract>