Metal‐Free Decarboxylative Cyclization/Ring Expansion: Construction of Five‐, Six‐, and Seven‐Membered Heterocycles from 2‐Alkynyl Benzaldehydes and Cyclic Amino Acids1. Issue 33 (6th July 2015)

• Record Type: Journal Article
• Authors: Samala, Srinivas; Singh, Gajendra; Kumar, Ravi; Ampapathi, Ravi Sankar; Kundu, Bijoy
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 33(2015)
• Page Start: 9564
• Page End: 9567
• Publication Date: 2015-07-06
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201504429
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A one pot synthesis of 1<italic>H</italic>‐benzo[g]indoles, tetrahydrobenzo[h]quinolines, and naphtho[1, 2‐b]azepines from 2‐alkynyl benzaldehydes and cyclic amino acids is reported. The salient feature of the strategy involves formation of three new bonds (one CN and two CC bonds) by a metal‐free decarboxylation/cyclization/one‐carbon ring expansion sequence in one pot.</p> </abstract>