Selective Monoarylation of Primary Amines Using the Pd‐PEPPSI‐IPentCl Precatalyst1. (10th June 2015)

• Record Type: Journal Article
• Authors: Sharif, Sepideh; Rucker, Richard P.; Chandrasoma, Nalin; Mitchell, David; Rodriguez, Michael J.; Froese, Robert D. J.; Organ, Michael G.
• Is Part Of: Angewandte Chemie. Volume 127:Number 33(2015)
• Page Start: 9643
• Page End: 9647
• Publication Date: 2015-06-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201502822
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A single set of reaction conditions for the palladium‐catalyzed amination of a wide variety of (hetero)aryl halides using primary alkyl amines has been developed. By combining the exceptionally high reactivity of the Pd‐PEPPSI‐IPent^Cl catalyst (PEPPSI=pyridine enhanced precatalyst preparation, stabilization, and initiation) with the soluble and nonaggressive sodium salt of BHT (BHT=2, 6‐di‐<italic>tert</italic>‐butyl‐hydroxytoluene), both six‐ and five‐membered (hetero)aryl halides undergo efficient and selective amination.</p> </abstract>