Systematic analysis of factors associated with progression and regression of ulcerative colitis in 918 patients. Issue 5 (6th July 2015)

• Record Type: Journal Article
• Authors: Safroneeva, E.; Vavricka, S.; Fournier, N.; Seibold, F.; Mottet, C.; Nydegger, A.; Ezri, J.; Straumann, A.; Rogler, G.; Schoepfer, A. M.; the Swiss IBD Cohort Study Group; Bauerfeind, Peter; Beglinger, Christoph; Begré, Stefan; Bengoa, José; Binek, Janek; Boller, Daniel; Borovicka, Jan; Braegger, Christian; Burnand, Bernard; Camara, Rafael; Criblez, Dominique; de Saussure, Philippe; Degen, Lukas; Delarive, Joakim; Ehmann, Tobias; Engelmann, Matthias; Wafa, Ali El; Felley, Christian; Frei, Alain; Frei, Pascal; Frei, Remus; Fried, Michael; Froehlich, Florian; Gallot‐Lavallée, Suzanne; Gerlach, Tilman; Geyer, Martin; Girardin, Marc; Goetze, Oliver; Haack, Horst; Hediger, Serge; Hengstler, Peter; Heyland, Klaas; Janiak, Patrick; Juillerat, Pascal; Brondolo, Vera Kessler; Knoblauch, Christoph; Kullak‐Ublick, Gerd A.; Maillard, Michel; Manser, Christine; Marbet, Urs; Manz, Michael; Meier, Rémy; Meyenberger, Christa; Michetti, Pierre; Mottet, Christian; Müller, Christoph; Müllhaupt, Beat; Nicolet, Thierry; Nydegger, Andreas; Piccoli, Franziska; Pilz, Julia; Pittet, Valérie; Rentsch, Ronald; Rey, Jean‐Pierre; Rogler, Daniela; Rogler, Gerhard; Sagmeister, Markus; Sauter, Bernhard; Schaub, Niklaus; Schibli, Susanne; Schoepfer, Alain M.; Seibold, Frank; Spalinger, Johannes; Stadler, Philippe; Steuerwald, Michael; Straumann, Alex; Sulz, Michael; Thorens, Joël; Vader, John‐Paul; Vavricka, Stephan R.; Vögtlin, Jürg; Von Känel, Roland; Wachter, Gert; Wermuth, Jürg; Wiesel, Paul;
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 42:Issue 5(2015)
• Page Start: 540
• Page End: 548
• Publication Date: 2015-07-06
• Subjects: Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.13307
• Languages: English
• ISSNs: 0269-2813

Abstract

<abstract abstract-type="main" id="apt13307-abs-0001"> <title>Summary</title> <sec id="apt13307-sec-0001" sec-type="section"> <title>Background</title> <p>Studies that systematically assess change in ulcerative colitis (UC) extent over time in adult patients are scarce.</p> </sec> <sec id="apt13307-sec-0002" sec-type="section"> <title>Aim</title> <p>To assess changes in disease extent over time and to evaluate clinical parameters associated with this change.</p> </sec> <sec id="apt13307-sec-0003" sec-type="section"> <title>Methods</title> <p>Data from the Swiss IBD cohort study were analysed. We used logistic regression modelling to identify factors associated with a change in disease extent.</p> </sec> <sec id="apt13307-sec-0004" sec-type="section"> <title>Results</title> <p>A total of 918 UC patients (45.3% females) were included. At diagnosis, UC patients presented with the following disease extent: proctitis [199 patients (21.7%)], left‐sided colitis [338 patients (36.8%)] and extensive colitis/pancolitis [381 (41.5%)]. During a median disease duration of 9 [4–16] years, progression and regression was documented in 145 patients (15.8%) and 149 patients (16.2%) respectively. In addition, 624 patients (68.0%) had a stable disease extent. The following factors were identified to be associated with disease progression: treatment with systemic glucocorticoids [odds ratio (OR) 1.704, <italic>P</italic> = 0.025] and calcineurin inhibitors (OR: 2.716, <italic>P</italic> = 0.005). No specific factors were found to be associated with disease regression.</p> </sec> <sec id="apt13307-sec-0005" sec-type="section"> <title>Conclusions</title> <p>Over a median disease duration of 9 [4–16] years, about two‐thirds of UC patients maintained the initial disease extent; the remaining one‐third had experienced either progression or regression of the disease extent.</p> </sec> </abstract>