Different clinical factors associated with Staphylococcus aureus and Pseudomonas aeruginosa in chronic rhinosinusitis. Issue 8 (21st April 2015)

• Record Type: Journal Article
• Authors: Zhang, Zi; Adappa, Nithin D.; Doghramji, Laurel J.; Chiu, Alexander G.; Cohen, Noam A.; Palmer, James N.
• Is Part Of: International forum of allergy & rhinology. Volume 5:Issue 8(2015:Aug.)
• Page Start: 724
• Page End: 733
• Publication Date: 2015-04-21
• Subjects: 617.51005
• DOI: 10.1002/alr.21532
• Languages: English
• ISSNs: 2042-6976

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="alr21532-sec-0010" sec-type="section"> <title>Background</title> <p> <italic>Staphylococcus aureus</italic> and <italic>Pseudomonas aeruginosa</italic> are common culture isolates in chronic rhinosinusitis (CRS). We aimed to determine whether they were associated with different clinical factors of CRS.</p> </sec> <sec id="alr21532-sec-0020" sec-type="section"> <title>Methods</title> <p>Adult CRS patients who underwent functional endoscopic sinus surgery (FESS) between October 1, 2007 and December 31, 2011 were recruited. Patient demographics, Lund‐Mackay computed tomography (CT) scores, 22‐item Sino‐Nasal Outcome Test (SNOT‐22) scores, disease characteristics, and medication use were collected prior to FESS. Intraoperative culture was obtained in a standard manner. We compared patients with isolates of <italic>S. aureus</italic> or <italic>P. aeruginosa</italic> to patients with other culture results and no bacterial growth, respectively. Multivariate logistic regression was performed.</p> </sec> <sec id="alr21532-sec-0030" sec-type="section"> <title>Results</title> <p>A total of 376 patients met criteria; 104 patients (28%) had <italic>S. aureus</italic>, 32 (9%) had <italic>P. aeruginosa</italic>, and 10 patients (3%) had no bacterial growth. After adjusting for all clinical factors, compared to patients with positive culture other than <italic>S. aureus</italic>, patients with <italic>S. aureus</italic> had 1.9 times increased odds of having nasal polyps (odds ratio [OR] = 1.9; 95% confidence interval [CI], 1.0 to 3.3; <italic>p</italic> = 0.036); when compared to patients with positive culture other than <italic>P. aeruginosa</italic>, patients with <italic>P. aeruginosa</italic> had 7.8 times increased odds of having prior FESS (OR = 7.8; 95% CI, 2.1 to 28.9; <italic>p</italic> = 0.002) (91% vs 58%; <italic>p</italic> < 0.001) and 3.6 times increased odds of having diabetes with marginal significance (OR = 3.6; 95% CI, 1.0 to 13.2; <italic>p</italic> = 0.053). The sample size in the no bacterial growth group was too small to draw firm conclusions.</p> </sec> <sec id="alr21532-sec-0040" sec-type="section"> <title>Conclusion</title> <p> <italic>S. aureus</italic> was more common in CRS patients with nasal polyps, whereas <italic>P. aeruginosa</italic> was more common in CRS patients with prior FESS history and possibly diabetes.</p> </sec> </abstract>