Association between concurrent genital bleeding and cervical cancer: a cross‐sectional study. (17th June 2015)

• Record Type: Journal Article
• Authors: Xavier‐Júnior, José C.C.; Vale, Diama B.; Zeferino, Luiz C.; dufloth, Rozany M.
• Is Part Of: Acta obstetricia et gynecologica Scandinavica. Volume 94:Number 9(2015)
• Page Start: 949
• Page End: 953
• Publication Date: 2015-06-17
• Subjects: Gynecology -- Periodicals; Pregnancy -- Periodicals; Obstetrics -- Periodicals; 618.05
• DOI: 10.1111/aogs.12682
• Languages: English
• ISSNs: 0001-6349

Abstract

<abstract abstract-type="main" id="aogs12682-abs-0001"> <title>Abstract</title> <sec id="aogs12682-sec-0001" sec-type="section"> <title>Introduction</title> <p>Genital bleeding may be a common symptom among women with cervical cancer.</p> </sec> <sec id="aogs12682-sec-0002" sec-type="section"> <title>Material and methods</title> <p>Cross‐sectional study evaluating whether the prevalence of cervical smear results is different in women with and without clinical information about concurrent genital bleeding.</p> </sec> <sec id="aogs12682-sec-0003" sec-type="section"> <title>Results</title> <p>The sample consisted of 2 324 836 smears; of these, 0.4% had clinical information on genital bleeding. When stratified by age group, women with genital bleeding had a higher chance of a cytological result of a high‐grade squamous intraepithelial lesion [30–49 years odds ratio (OR) 2.38; 95% confidence interval (CI) 1.60–3.53 and ≥50 years OR 6.30; 95%CI 3.72–10.67), of squamous cell carcinoma (SCC) (30–49 years OR 24.70; 95%CI 11.96–51.03 and ≥50 years OR 48.91; 95%CI 31.28–76.47) and of atypical glandular cells (30–49 years OR 5.72; 95%CI 3.30–9.93 and ≥50 years OR 11.56; 95%CI 5.96–22.45); there was also a higher chance of adenocarcinoma for women ≥50 years (OR 53.13; 95%CI 28.08–100.51). The sensitivity of genital bleeding for women aged 18–29 years was 0.4% for high‐grade squamous intraepithelial lesion (HSIL); for women 30–49 years old the rate was 0.9% for HSIL, 8.6% for SCC and 2.1% for atypical glandular cells of undetermined significance (AGUS), while for women aged from 50 years or more the rates were 2.0% for HSIL, 13.7% for SCC, 3.6% for AGUS and 14.7% for adenocarcinoma.</p> </sec> <sec id="aogs12682-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Women ≥30 years old with genital bleeding should be referred for colposcopy to rule out the possibility of cervical cancer.</p> </sec> </abstract>