Discovery of a series of 2-phenylnaphthalenes as firefly luciferase inhibitors1. Issue 78 (26th August 2015)

• Record Type: Journal Article
• Authors: Bai, Haixiu; Chen, Wang; Wu, Wenxiao; Ma, Zhao; Zhang, Huateng; Jiang, Tianyu; Zhang, Tianchao; Zhou, Yubin; Du, Lupei; Shen, Yuemao; Li, Minyong
• Is Part Of: RSC advances. Volume 5:Issue 78(2015)
• Page Start: 63450
• Page End: 63457
• Publication Date: 2015-08-26
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra12886b
• Languages: English
• ISSNs: 2046-2069

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2b39hqmd" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />A series of 2-phenylnaphthalenes as firefly luciferase inhibitors are reported. The most potent compound 5 showed good systemic inhibition in transgenic mice. Kinetic assay indicated 5 is competitive for aminoluciferin and noncompetitive for ATP.</p> </abstract>