Glutamine-chitosan modified calcium phosphate nanoparticles for efficient siRNA delivery and osteogenic differentiation1. Issue 31 (21st August 2015)

• Record Type: Journal Article
• Authors: Choi, Bogyu; Cui, Zhong-Kai; Kim, Soyon; Fan, Jiabing; Wu, Benjamin M.; Lee, Min
• Is Part Of: Journal of materials chemistry. Volume 3:Issue 31(2015)
• Page Start: 6448
• Page End: 6455
• Publication Date: 2015-08-21
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c5tb00843c
• Languages: English
• ISSNs: 2050-750X

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2b2vs5t2" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />CaP nanoparticles coated with highly cationic, glutamine-conjugated oligochitosan (Gln-OChi) are developed for siRNA delivery to significantly enhance gene transfection and knockdown efficiency with minimal cytotoxicity. This new nanocarrier can potentially be used for gene therapy.</p> </abstract>