Highly enantioselective synthesis of non-natural aliphatic α-amino acids via asymmetric hydrogenation1. Issue 28 (28th July 2015)

• Record Type: Journal Article
• Authors: Ji, Jianjian; Chen, Caiyou; Cai, Jiayu; Wang, Xinrui; Zhang, Kai; Shi, Liyang; Lv, Hui; Zhang, Xumu
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 28(2015)
• Page Start: 7624
• Page End: 7627
• Publication Date: 2015-07-28
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob01111f
• Languages: English
• ISSNs: 1477-0520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj26bckj3s" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />A series of non-natural aliphatic α-amino acids were synthesized with high ee and yield by employing a rhodium–Duanphos complex as the catalyst. An efficient approach for the synthesis of the intermediate of the anti-diabetic drugs Alogliptin and Linagliptin in the DPP-4 inhibitor class was also developed.</p> </abstract>