An investigation of nitrile transforming enzymes in the chemo-enzymatic synthesis of the taxol sidechain1. Issue 28 (28th July 2015)

• Record Type: Journal Article
• Authors: Wilding, Birgit; Veselá, Alicja B.; Perry, Justin J. B.; Black, Gary W.; Zhang, Meng; Martínková, Ludmila; Klempier, Norbert
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 28(2015)
• Page Start: 7803
• Page End: 7812
• Publication Date: 2015-07-28
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob01191d
• Languages: English
• ISSNs: 1477-0520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj26bckrfd" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />Nitrile transforming enzymes, namely nitrilases and nitrile hydratases, are investigated for the enzymatic hydrolysis of two taxol sidechain precursors, an openchain α-hydroxy-β-amino nitrile and a cyanodihydrooxazole.</p> </abstract>