A highly sensitive fluorescent light-up probe for real-time detection of the endogenous protein target and its antagonism in live cells1. Issue 29 (7th August 2015)

• Record Type: Journal Article
• Authors: Geng, Junlong; Goh, Walter L.; Zhang, Chongjing; Lane, David P.; Liu, Bin; Ghadessy, Farid; Tan, Yen Nee
• Is Part Of: Journal of materials chemistry. Volume 3:Issue 29(2015)
• Page Start: 5933
• Page End: 5937
• Publication Date: 2015-08-07
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c5tb00819k
• Languages: English
• ISSNs: 2050-750X

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj26b8hbpr" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />A target-specific switchable fluorescent probe for cellular Mdm2 protein detection (off–on) and drug discovery applications (on–off) targeting the p53 pathway.</p> </abstract>