A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine1. Issue 29 (7th August 2015)

• Record Type: Journal Article
• Authors: Smith, Mark E. B.; Caspersen, Mikael B.; Robinson, Eifion; Morais, Maurício; Maruani, Antoine; Nunes, João P. M.; Nicholls, Karl; Saxton, Malcolm J.; Caddick, Stephen; Baker, James R.; Chudasama, Vijay
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 29(2015)
• Page Start: 7946
• Page End: 7949
• Publication Date: 2015-08-07
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob01205h
• Languages: English
• ISSNs: 1477-0520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2687skxt" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />Thiol-stable albumin biologics are enabled by controlled, quantitative hydrolysis of maleimide–albumin conjugates, <italic>i.e.</italic> with no retro-Michael.</p> </abstract>