Chloroquinoline–acetamide hybrids: a promising series of potential antiprotozoal agents1. Issue 60 (2nd July 2015)

• Record Type: Journal Article
• Authors: Inam, Afreen; Van Zyl, Robyn L.; van Vuuren, Natasha J.; Chen, Chien-Teng; Avecilla, Fernando; Agarwal, Subhash M.; Azam, Amir
• Is Part Of: RSC advances. Volume 5:Issue 60(2015)
• Page Start: 48368
• Page End: 48381
• Publication Date: 2015-07-02
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra05472a
• Languages: English
• ISSNs: 2046-2069

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj1zk6gjbv" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />In an endeavour to develop efficacious antiprotozoal agents chloroquinoline–acetamide hybrids were synthesized and screened <italic>in vitro</italic> against <italic>E. histolytica</italic> and <italic>P. falciparum</italic> and molecular docking studies were performed against PfDHFR.</p> </abstract>