Controlling the Structure and Length of Self‐Synthesizing Supramolecular Polymers through Nucleated Growth and Disassembly1. Issue 27 (27th May 2015)

• Record Type: Journal Article
• Authors: Pal, Asish; Malakoutikhah, Morteza; Leonetti, Giulia; Tezcan, Meniz; Colomb‐Delsuc, Mathieu; Nguyen, Van Duc; van der Gucht, Jasper; Otto, Sijbren
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 27(2015)
• Page Start: 7852
• Page End: 7856
• Publication Date: 2015-05-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201501965
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Directing self‐assembly processes out‐of‐equilibrium to yield kinetically trapped materials with well‐defined dimensions remains a considerable challenge. Kinetically controlled assembly of self‐synthesizing peptide‐functionalized macrocycles through a nucleation–growth mechanism is reported. Spontaneous fiber formation in this system is effectively shut down as most of the material is diverted into metastable non‐assembling trimeric and tetrameric macrocycles. However, upon adding seeds to this mixture, well‐defined fibers with controllable lengths and narrow polydispersities are obtained. This seeded growth strategy also allows access to supramolecular triblock copolymers. The resulting noncovalent assemblies can be further stabilized through covalent capture. Taken together, these results show that self‐synthesizing materials, through their interplay between dynamic covalent bonds and noncovalent interactions, are uniquely suited for out‐of‐equilibrium self‐assembly.</p> </abstract>