Catalytic Asymmetric Synthesis of Phosphine Boronates1. (7th May 2015)

• Record Type: Journal Article
• Authors: Hornillos, Valentín; Vila, Carlos; Otten, Edwin; Feringa, Ben L.
• Is Part Of: Angewandte Chemie. Volume 127:Number 27(2015)
• Page Start: 7978
• Page End: 7982
• Publication Date: 2015-05-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201502987
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The first catalytic enantioselective synthesis of ambiphilic phosphine boronate esters is presented. The asymmetric boration of α, β‐unsaturated phosphine oxides catalyzed by a copper bisphosphine complex affords optically active organoboronate esters that bear a vicinal phosphine oxide group in good yields and high enantiomeric excess. The synthetic utility of the products is demonstrated through stereospecific transformations into multifunctional optically active compounds.</p> </abstract>