Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)1. Issue 53 (7th July 2015)

• Record Type: Journal Article
• Authors: Nunes, João P. M.; Morais, Maurício; Vassileva, Vessela; Robinson, Eifion; Rajkumar, Vineeth S.; Smith, Mark E. B.; Pedley, R. Barbara; Caddick, Stephen; Baker, James R.; Chudasama, Vijay
• Is Part Of: Chemical communications. Volume 51:Issue 53(2015)
• Page Start: 10624
• Page End: 10627
• Publication Date: 2015-07-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc03557k
• Languages: English
• ISSNs: 1359-7345

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj146s1jc3" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />A next generation maleimide–ADC is shown to have excellent stability in blood serum, as well as high potency and selectivity <italic>in vitro</italic>.</p> </abstract>