Preparation and characterization of glycyrrhetinic acid-modified stearic acid-grafted chitosan micelles*. (August 2015)

• Record Type: Journal Article
• Authors: Chen, Qian; Sun, Yong; Wang, Jiangjun; Yan, Guowen; Cui, Zhaoyuan; Yin, Hongli; Wei, Haitian
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 43:Number 4(2015:Aug.)
• Page Start: 217
• Page End: 223
• Publication Date: 2015-08
• Subjects: Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• Languages: English
• ISSNs: 2169-1401

Abstract

<abstract> <title>Abstract</title> <p>Stearic acid-grafted chitosan (CS-SA) and glycyrrhetinic acid-conjugated stearic acid-grafted chitosan (GA-CS-SA) were synthesized and were further used for the preparation of micelles. The substitution degree (SD) of SA and GA on CS was measured. The physicochemical properties of CS-SA and GA-CS-SA micelles such as critical micelle concentration (CMC), aggregation number of hydrophobic micro-domain (AN), particle size, zeta potential, and morphology were also determined. The CMC of GA-CS-SA was about 17.49 μg/mL, which was relatively low. Its AN was 2.09. The GA-CS-SA micelles showed spherical shape with mean diameter of 121.1 nm and had positive charge, which suggested that GA-CS-SA could be a good carrier of cancer drug.</p> </abstract>