Metabolic syndrome in Spanish patients with psoriasis needing systemic therapy: Prevalence and association with cardiovascular disease in PSO-RISK, a cross-sectional study. (August 2015)

• Record Type: Journal Article
• Authors: Belinchón, I.; Vanaclocha, F.; de la Cueva-Dobao, P.; Coto-Segura, P.; Labandeira, J.; Herranz, P.; Taberner, R.; Juliá, B.; Cea-Calvo, L.; Puig, L.
• Is Part Of: Journal of dermatological treatment. Volume 26:Number 4(2015:Aug.)
• Page Start: 318
• Page End: 325
• Publication Date: 2015-08
• Subjects: Skin -- Diseases -- Treatment -- Periodicals; Skin Diseases -- drug therapy -- Periodicals; Skin Diseases -- therapy -- Periodicals; 616.5
• Languages: English
• ISSNs: 0954-6634

Abstract

<abstract> <title>Abstract</title> <p> <italic>Background</italic>: Increasing evidence indicates a relationship between psoriasis and metabolic syndrome (MS). We evaluated the prevalence of MS in patients receiving systemic treatment for psoriasis in Spain, and its relationship to cardiovascular disease (CVD).</p> <p> <italic>Methods</italic>: This cross-sectional, multicenter, non-interventional study enrolled 368 patients with moderate-to-severe psoriasis requiring systemic treatment. Clinical parameters for psoriasis, CV risk factors, MS and CVD were assessed. Descriptive and logistic regression analyses were performed.</p> <p> <italic>Results</italic>: 352 patients were included (median psoriasis duration: 18 years, plaque psoriasis [95.7%], psoriatic arthritis [22.8%]). Overall, 132 patients (37.5%) fulfilled diagnostic criteria for MS; the most prevalent MS components were high blood pressure and increased waist circumference. Patients with MS were older, more likely to be obese and to have a sedentary lifestyle and hypercholesterolemia than those without MS. CVD was more prevalent in patients with MS than in those without (29.5% versus 15.9%, <italic>p</italic> = 0.002), particularly coronary heart disease (CHD), myocardial infarction and heart failure. MS was independently associated with CVD (OR 1.98, <italic>p</italic> = 0.018) and CHD (OR 2.02, <italic>p</italic> = 0.044).</p> <p> <italic>Conclusion</italic>: The prevalence of MS was high among patients with moderate-to-severe psoriasis requiring systemic treatment, and was associated with a higher prevalence of CVD. Dermatologists should consider implementing simple screening protocols.</p> </abstract>