Prognostic Significance of Ki67 Expression in Malignant Peritoneal Mesothelioma. (August 2015)

• Record Type: Journal Article
• Authors: Pillai, Krishna; Pourgholami, Mohammad H.; Chua, Terence C.; Morris, David L.
• Is Part Of: American journal of clinical oncology. Volume 38:Number 4(2015)
• Publication Date: 2015-08
• Subjects: Cancer -- Treatment -- Periodicals; Oncology -- Periodicals; Tumors -- Periodicals; 616.994005
• DOI: 10.1097/COC.0b013e3182a0e867
• Languages: English
• ISSNs: 0277-3732

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objectives:</title> <p>Although Ki67 measurement by immunohistochemistry has been widely used as a prognostic index in cancers, it has not been reported in malignant peritoneal mesothelioma (MPM). Hence, this study examines the prognostic significance of Ki67 in MPM.</p> </sec> <sec> <title>Methods:</title> <p>Specimens from 42 MPM patients were screened for Ki67 expression using immunohistochemistry. Ki67 expression was classified into 2 groups on the basis of expression (<25%=low; ≥25%=high) using standard methods. Using Kaplan-Meier survival analysis, the significance of Ki67 was assessed in different clinicopathologic categories.</p> </sec> <sec> <title>Results:</title> <p>High expression of Ki67 (≥25% by immunohistochemical evaluation) was correlated with poor survival in the overall group (<italic>P</italic>=0.001); male sex (<italic>P</italic>=0.001); female sex (<italic>P</italic>=0.001); epithelioid tumors (<italic>P</italic>=0.001): male epithelioid (<italic>P</italic>=0.001), female epithelioid (<italic>P</italic>=0.003); peritoneal cancer index (PCI): PCI<20 (<italic>P</italic>=0.001), PCI≥20 (<italic>P</italic>=0.002); and age at diagnosis (AAD): AAD<60 years (<italic>P</italic>=0.001), AAD≥60 years (<italic>P</italic>=0.004). Independent of Ki67, male sex (<italic>P</italic>=0.007), sarcomatoid histology (<italic>P</italic>=0.001), PCI≥20 (<italic>P</italic>=0.013), and AAD≥60 years (<italic>P</italic>=0.004) correlated with poor survival. Multivariate analysis showed that only AAD≥60 years (<italic>P</italic>=0.049) and high Ki67 expression for all tumors (<italic>P</italic>=0.031), male sex (<italic>P</italic>=0.038), female sex (<italic>P</italic>=0.021), epithelioid tumors (<italic>P</italic>=0.044), and AAD<60 years (<italic>P</italic>=0.029) were statistically significant.</p> </sec> <sec> <title>Conclusions:</title> <p>Ki67 expression affects prognosis in MPM patients and helps to predict survival within the various clinicopathologic categories.</p> </sec> </abstract>