Biomarkers of inflammation in HIV-infected Peruvian men and women before and during suppressive antiretroviral therapy. (24th August 2015)

• Record Type: Journal Article
• Authors: Ticona, Eduardo; Bull, Marta E.; Soria, Jaime; Tapia, Kenneth; Legard, Jillian; Styrchak, Sheila M.; Williams, Corey; Mitchell, Caroline; Rosa, Alberto L.A.; Coombs, Robert W.; Frenkel, Lisa M.
• Is Part Of: AIDS. Volume 29:Number 13(2015)
• Publication Date: 2015-08-24
• Subjects: AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome; AIDS (Disease); Periodicals; Periodicals; 616.9792005
• DOI: 10.1097/QAD.0000000000000758
• Languages: English
• ISSNs: 0269-9370

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objective:</title> <p>Inflammatory biomarkers associated with cardiovascular disease are elevated in HIV-infected persons. These biomarkers improve with antiretroviral therapy (ART) but do not normalize to values observed in HIV-uninfected adults. Little is known regarding biomarkers of inflammation in HIV-infected Peruvians, in whom an increased burden of infectious diseases may exacerbate inflammation, and women, in whom sex difference may alter inflammation compared with men.</p> </sec> <sec> <title>Methods:</title> <p>Peruvians initiating first-line ART were enrolled in a prospective observational study. Individuals with suppression of HIV RNA plasma loads to less than 30 copies/ml when determined quarterly over 24 months of ART, had biomarkers of inflammation and cellular activation measured pre-ART and at 24-months of ART, and evaluated for associations with sex and clinical parameters.</p> </sec> <sec> <title>Results:</title> <p>Pre-ART high-sensitivity C-reactive protein (hsCRP) values of men were in the high-risk cardiovascular disease category (>3.0 mg/l) more frequently compared with women (<italic>P</italic> = 0.02); most women's values were in the low/average-risk categories. At 24 months of suppressive ART, hsCRP concentrations decreased in men (<italic>P</italic> = 0.03), but tended to increase in women, such that the proportion with high-risk hsCRP did not differ by sex. Pre-ART, soluble CD163 concentrations were higher in women compared with men (<italic>P</italic> = 0.02), and remained higher after 24 months of suppressive ART (<italic>P</italic> = 0.02). All other inflammatory biomarkers (<italic>P</italic> < 0.03) decreased across sexes. Biomarker concentrations were not associated with BMI or coinfections.</p> </sec> <sec> <title>Conclusion:</title> <p>Elevated inflammatory biomarkers persisted despite 24 months of suppressive ART in a subset of Peruvians, and to a greater extent in women compared with men. These findings suggest that lifestyle or pharmacologic interventions may be required to optimize the health of HIV-infected Peruvians, particularly women.</p> </sec> </abstract>