Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and fluorouracil-based treatment in Taiwan colorectal cancer. Issue 8 (September 2015)

• Record Type: Journal Article
• Authors: Wu, Nai-Chun; Su, Shih-Ming; Lin, Tai-Jung; Chin, Jen; Hou, Chun-Fang; Yang, Jhong-Ying; Liu, Wen-Sheng; Chang, Li-Ching
• Is Part Of: Anti-cancer drugs. Volume 26:Issue 8(2015)
• Publication Date: 2015-09
• Subjects: Antineoplastic agents -- Periodicals; Cancer -- Chemotherapy -- Periodicals; Antineoplastic Agents -- therapeutic use -- Periodicals; Drug Therapy -- Periodicals; 616.994061
• DOI: 10.1097/CAD.0000000000000261
• Languages: English
• ISSNs: 0959-4973

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p>This study aimed to investigate the association between methylenetetrahydrofolate reductase (<italic>MTHFR</italic>) gene polymorphisms and the prognosis of colorectal cancer (CRC) patients undergoing 5-fluorouracil (5-FU)-based chemotherapy in Taiwan. We investigated 126 CRC cases. The most common polymorphisms C677T (rs1801133) and A1298C (rs1801131) in <italic>MTHFR</italic> were genotyped using PCR-restriction fragment length polymorphism. The frequencies of C677T and A1298C were further compared with those in the HapMap database for Whites and Asians. In this study, we found that TT-homozygosity at <italic>MTHFR</italic> C677T was significantly associated with survival in CRC patients [<italic>P</italic><0.001; 95% confidence interval (CI)=0.068–0.212]. In CRC patients receiving 5-FU-based chemotherapy, the TT genotype at C677T was also significantly associated with survival (<italic>P</italic>=0.001; 95% CI=0.113–0.400) and recurrence after surgery (<italic>P</italic><0.001; 95% CI=0.295–0.609). The A1298C genotypes had a significant impact on survival (<italic>χ</italic><sup>2</sup>=7.103; <italic>P</italic>=0.029). The <italic>MTHFR</italic> A1298C CC genotype may increase the risk of death in Taiwanese CRC patients. The <italic>MTHFR</italic> C677T TT genotype was present at a lower frequency in our CRC patients than in the HapMap Asian population, but the frequency was similar to that in Whites in the HapMap database. The distribution of <italic>MTHFR</italic> A1298C genotypes was similar in our CRC and in the HapMap Asian population, but was different from that in the White population. This study suggested that <italic>MTHFR</italic> C677T and A1298C are associated with prognosis in CRC patients undergoing 5-FU-based chemotherapy.</p> </sec> </abstract>