HER3 expression in primary colorectal cancer including corresponding metastases in lymph node and liver. (April 2015)

• Record Type: Journal Article
• Authors: Lédel, Frida; Stenstedt, Kristina; Hallström, Marja; Ragnhammar, Peter; Edler, David
• Is Part Of: Acta oncologica. Volume 54:Number 4(2015)
• Page Start: 480
• Page End: 486
• Publication Date: 2015-04
• Subjects: Oncology -- Periodicals; Cancer -- Treatment -- Periodicals; 616.992
• Languages: English
• ISSNs: 0284-186X

Abstract

<abstract> <title>Abstract</title> <p> <bold>Background.</bold> The human epidermal growth factor receptor complex (EGFR-1, HER2, HER3 and HER4) plays an important role in pathogenesis of solid tumours. We have previously reported high expression of HER3 in 70% of primary colorectal cancer (CRC) and that high expression were linked to a worse clinical outcome. The purpose of this study is to evaluate the HER3 expression in primary CRC and metastases.</p> <p> <bold>Material and methods.</bold> Tissue samples from primary CRC, corresponding lymph node metastases and liver metastases from 107 patients were analysed by immunohistochemistry.</p> <p> <bold>Results.</bold> Of 107 patients, 80% showed high HER3 expression in primary CRC tumours and 81% of the stage III patients presented high expression in the lymph node metastases. All patients had liver metastases and 82% presented high HER3 expression. HER3 expression in primary tumour correlated with expression in the corresponding lymph node metastases (r = 0.65, p &lt; 0.001) and in the liver metastases (r = 0.45, p &lt; 0.001). A correlation between HER3 expression in corresponding lymph node and liver metastases (r = 0.65, p &lt; 0.001) was seen.</p> <p> <bold>Conclusion.</bold> High HER3 expression is seen in about 80% of primary CRC, corresponding lymph node metastases and liver metastases. There is a correlation between HER3 expression in primary tumour and metastases in CRC.</p> </abstract>