Metabolic regulation in model ascomycetes – adjusting similar genomes to different lifestyles. Issue 8 (August 2015)

• Record Type: Journal Article
• Authors: Whiteway, Malcolm; Tebung, Walters A.; Choudhury, Baharul I.; Rodríguez-Ortiz, Roberto
• Is Part Of: Trends in genetics. Volume 31:Issue 8(2015)
• Page Start: 445
• Page End: 453
• Publication Date: 2015-08
• Subjects: Genetics -- Periodicals; 576.5
• DOI: 10.1016/j.tig.2015.05.002
• Languages: English
• ISSNs: 0168-9525

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005"> <italic>S. cerevisiae</italic> and <italic>C. albicans</italic> have similar genomic constitutions, but very dissimilar lifestyles.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">These yeasts regulate their central metabolism by a variety of mechanisms – this control allows their similar genomes to generate different lifestyles.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">This regulatory rewiring was initially identified as changes in specific transcription factors; we now see rewiring in post-translational controls as well as changes to the various general transcriptional control complexes.</p> </list-item> </list> </p> </sec> </abstract>