A split-mouth, randomized, triple-blind, placebo-controlled study to analyze the pre-emptive effect of etoricoxib 120 mg on inflammatory events following removal of unerupted mandibular third molars. Issue 9 (September 2015)

• Record Type: Journal Article
• Authors: Costa, F.W.G.; Soares, E.C.S.; Esses, D.F.S.; Silva, P.G. deB.; Bezerra, T.P.; Scarparo, H.C.; Ribeiro, T.R.; Fonteles, C.S.R.
• Is Part Of: International journal of oral & maxillofacial surgery. Volume 44:Issue 9(2015:Sep.)
• Page Start: 1166
• Page End: 1174
• Publication Date: 2015-09
• Subjects: Mouth -- Surgery -- Periodicals; Maxilla -- Surgery -- Periodicals; Dentistry -- Periodicals; Dentistry, Operative; Oral Surgical Procedures; Surgery, Oral; Dentistry; Maxilla -- Surgery; Mouth -- Surgery; Electronic journals; Periodicals; 617.52059
• DOI: 10.1016/j.ijom.2015.06.012
• Languages: English
• ISSNs: 0901-5027

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <p id="spar0005">Pain after third molar extraction has been considered the most suitable pharmaceutical model to evaluate acute pain. This study aimed to evaluate the pre-emptive analgesic/anti-inflammatory efficacy of etoricoxib 120 mg following mandibular third molar surgery. A split-mouth, randomized, triple-blind, placebo-controlled study was conducted with patients undergoing the surgical removal of mandibular third molars. All volunteers were allocated randomly to receive either etoricoxib 120 mg or placebo 1 h preoperatively, and inflammatory events were evaluated. An estimated sample of 18 surgical units per group was required based on a pilot study (95% confidence level and 80% statistical power). Rescue medication was analyzed by Kaplan–Meier method through log-rank Mantel–Cox test and Pearson linear correlation (<italic>P</italic> < 0.05). Pre-emptive etoricoxib reduced postoperative pain scores significantly in comparison to placebo (<italic>P</italic> < 0.001), with a pain score peak at 6 h after surgery (<italic>P</italic> < 0.001). The mean rescue medication consumption was lower in the etoricoxib group compared to the placebo group over the study period (<italic>P</italic> < 0.05). There was no statistically significant difference between groups related to swelling and trismus. The pre-emptive administration of etoricoxib 120 mg significantly reduced the postoperative pain intensity and the need for rescue medication, but did not reduce swelling or trismus.</p> </sec> </abstract>