Calreticulin gene mutations in myeloproliferative neoplasms without Janus kinase 2 mutations. Issue 6 (June 2015)

• Record Type: Journal Article
• Authors: Sun, Chao; Zhang, Sujiang; Li, Jianyong
• Is Part Of: Leukemia & lymphoma. Volume 56:Issue 6(2015:Jun.)
• Page Start: 1593
• Page End: 1598
• Publication Date: 2015-06
• Subjects: Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.3109/10428194.2014.953153
• Languages: English
• ISSNs: 1042-8194

Abstract

<abstract> <title>Abstract</title> <p>Calreticulin, an endoplasmic reticulum protein with multiple functions involving chaperone activity and calcium homeostasis, plays an important role in cellular proliferation and differentiation. Calreticulin dysfunction is known to be associated with different cancers. Very recently, calreticulin mutations have been identified in myeloproliferative neoplasms (MPNs), with a particularly high frequency in MPNs without Janus kinase 2 (<italic>JAK2</italic>) mutations, which exhibit clinical characteristics different from those with mutant <italic>JAK2</italic>. Here, we focus on the structure, function and carcinogenicity of calreticulin, as well as its relationship with MPNs not involving <italic>JAK2</italic> mutations.</p> </abstract>